靳振明,本科毕业于必赢线路检测3003no1,获生物技术学士学位; 毕业后保送至清华大学,直接攻读博士研究生,师从著名结构生物学家饶子和院士,获得生物学博士学位。现任湖南大学生物学院教授、博士生导师,主要研究方向为重要疾病与微生物的关键蛋白质结构解析及新药发现。作为主要研究者,率先解析全球首个新冠病毒蛋白质三维结构,研究成果入选“中国生命科学十大进展”、蛋白质结构数据库(PDB)明星分子等。研究发现的多种先导药物,在全球开展多中心I期/II期临床试验,并申请多项国内外专利。研究工作发表在Nature、Science、Nature Structural & Molecular Biology、Nature Communication、PNAS、Protein & Cell 等国内外主流学术期刊,并受邀在BBRC 等发表综述,累计引用量超过3000次。
2014.9-2021.1 清华大学生命科学学院,理学博士,导师:饶子和 院士;
2018.9-2020.8 上海科技大学免疫化学研究所,联合培养,导师:杨海涛 教授;
2010.9-2014.6 必赢线路检测3003no1,理学学士,导师:袁政 教授。
2021.12-至今 湖南大学生物学院,教授、博士生导师、岳麓学者
湖南大学蛋白质结构与新药发现实验室,拥有包含从大肠杆菌、酵母到昆虫细胞、哺乳动物细胞的全系统重组蛋白研究平台,具备丰富的蛋白结构生物学、分子生物学、生物化学、微生物研究手段,更拥有相关的药物研发和临床转化经验。主要从事重要疾病与微生物的关键蛋白质结构解析及新药发现研究工作,在分子层面深入研究疾病发病机制和药物作用机制,并针对性开发小分子药物、拟肽类药物、抗体、药物递送系统等治疗手段,推动基础研究向临床应用的转化。另外,课题组也面向植物领域的关键蛋白质开展结构生物学研究。
湖南大学高层次人才引进启动费,2021/12-2026/12,在研,主持
代表论文
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W. Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zhengli Shi, Hualiang Jiang, Zihe Rao, Haitao Yang. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature, 2020, 582: 289-293. (ESI热点+高被引论文,F1000推荐论文)
Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W. Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nature Structural & Molecular Biology, 2020, 27: 529-532. (ESI热点+高被引论文)
Yao Zhao, Yan Zhu, Xiang Liu, Zhenming Jin, Yinkai Duan, Qi Zhang, Chengyao Wu, Lu Feng, Xiaoyu Du, Jinyi Zhao, Maolin Shao, Bing Zhang, Xiuna Yang, Lijie Wu, Xiaoyun Ji, Luke W. Guddat, Kailin Yang, Zihe Rao, Haitao Yang. Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proceedings of the National Academy of Sciences, 2022, 119(16).
Zhenming Jin, Haofeng Wang, Yinkai Duan, Haitao Yang. The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2. Biochemical and Biophysical Research Communications, 2021, 538: 63-71.
Kangsa Amporndanai, Xiaoli Meng, Weijuan Shang, Zhenming Jin, Michael Rogers, Yao Zhao, Zihe Rao, Zhijie Liu, Haitao Yang, Leike Zhang, Paul M. O’Neill, S. Samar Hasnain. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. Nature Communication, 2021, 12: 3061.
Yao Zhao, Xiaoyu Du, Yinkai Duan, Xiaoyan Pan, Yifang Sun, Tian You, Lin Han, Zhenming Jin, Weijuan Shang, Jing Yu, Hangtian Guo, Qianying Liu, Yan Wu, Chao Peng, Jun Wang, Chenghao Zhu, Xiuna Yang, Kailin Yang, Ying Lei, Luke W. Guddat, Wenqing Xu, Gengfu Xiao, Lei Sun, Leike Zhang, Zihe Rao, Haitao Yang. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein & Cell, 2021, 12(11): 877-888.
Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang, Yechun Xu, Haitao Yang, Hong Liu.. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science, 2020, 368: 1331-1335. (封面论文,ESI高被引论文,F1000推荐论文)
靳振明, 平宝哲, 沈浩珺, 杜淮清, 李瑞乾, 朱璐, 张大兵, 袁政。水稻脆秆突变体bc-s1的表型分析和基因定位。植物学报, 2016, 51(2): 167-174.
Huanhuan Wang, Liang Zhang, Qiang Cai, Yun Hu, Zhenming Jin, Xiangxiang Zhao, Wei Fan, Qianming Huang, Zhijing Luo, Mingjiao Chen, Dabing Zhang, Zheng Yuan. OsMADS32 interacts with PI‐like proteins and regulates rice flower development. Journal of Integrative Plant Biology, 2015, 57(5): 504-513.
整理日期:2022年7月8日
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