报告题目：Towards Understanding Antiviral Drug Toxicity

主讲人：Whitney Yin

主讲人简介：Associate Professor and Assistant Director, Department of Pharmacology and Toxicology，The University of Texas Medical Branch at Galveston, Homepage: https://scsb.utmb.edu/faculty/Yin.asp

报告时间：2018年05月11日上午9:00-10:00

报告地点：生物药学楼2-116

联系人：郑舰艇 jtzheng@sjtu.edu.cn

主办单位：结构酶学课题组

报告摘要：Mitochondrial DNA and RNA polymerases are targets of antiviral drugs against HIV and HCV (hepatitis C virus), causing drug toxicity. We conducted enzymatic and structural studies to understand the molecular basis for drug toxicity. By comparative structural and functional studies of viral target and human adverse reaction target, we identified key features in the molecules to reduce drug toxicity while maintaining drug efficacy.