报告题目：Biotransformation of Aromatic Rings to Cyclohexadiene-diols

报 告  人：Dr. Simon Lewis      University of Bath

报告时间：11月12日下午14:00

报告地点：闵行校区生物药学楼2-116

联 系  人：林双君   This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

 

报告人介绍：We are interested in using bacteria to carry out dihydroxylation of aromatic rings—a process that is very difficult by conventional chemical means. Of the strains identified or engineered to date, the majority metabolise substituted arenes to dihydrodiols with the ortho,meta-substitution pattern.  Much rarer is the formation of ipso,ortho-substituted dihydrodiols.  We are exploiting the microbial ipso,ortho-dihydroxylation of benzoic acid, producing a versatile chiral building block for synthesis.