报告题目：The making of a worm: genes, cells and organisms

报 告  人：Zhirong Bao， Memorial Sloan Kettering Cancer Center

报告时间：星期四11月27日 14:00-15:00

报告地点：闵行校区生物药学楼2-123

联 系  人：韦朝春   This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract：A major challenge in developmental biology is to understand how networks of gene interactions give rise to cellular behaviors and how networks of cellular interactions give rise to the organism.  We have been taking a systems biology approach to address these question.  We have built a powerful platform for automated and systematic single-cell analysis of development in the C. elegans embryo.  It includes microscopy techniques for long-term 3D time-lapse imaging, image analysis software for automated cell tracking and cell lineage tracing, mapping gene expression onto individual, tracked cells, as well as systematic single-cell measurements of cellular behaviors during development that include proliferation, differentiation and morphogenesis.  More importantly, we have devised methods to infer mechanistic models of development from image data.  In this case, the model describes cell fate differentiation as trajectories of cell fates with a sequence of binary fate choices as well as predicted gene modules and cell-cell signaling events that regulate each binary choice.  I will discuss our most recent progress in analyzing 200 conserved emb genes, constructing a multi-scale model involving genes, cells and the embryo, and the challenges ahead in understanding how higher level properties of cells and the embryo emerge.