报告题目：The dark side of the genome : Transcription termination and the control of pervasive transcription.

报 告  人： Prof. Domenico Libri，The Institute Jacques Monodin Paris，CNRS-Université Paris Diderot.

报告时间：5月19日上午10:00-11:00

报告地点：闵行校区生命药学楼树华多功能厅

联 系  人：刘喜朋 This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

 

报告人介绍：

Domenico Libri is Director of Research at the CNRS, working at the Institute Jacques Monodin Paris. He has worked on alternative splicing for his PhD at the Pasteur Institute, France, and on the mechanism of splicing for his post-doc in Brandeis University, USA. As an independent group leader he studied mRNA export in yeast and RNA quality control. Together with two other groups, he first described the existence of cryptic non-coding transcriptsproduced by pervasive transcription, and studied the mechanism of their production and their function.

在Cell, Molecular Cell,Nat Rev Mol Cell Biol.,Nature Structure and Molecular Biology, EMBO Journal等期刊发表论文90多篇。

 

Abstract:

Transcription termination is essential, not only to define the 3’-end of transcripts and their fate, but also to prevent interference between adjacent regions of transcription and between transcription and other cellular events. Termination is also one of the main strategies that the cell employs to control pervasive/hidden transcription. In the last ten years or so it has become clear that transcription occurs largely outside of annotated regions, which produces a wealth of non-coding RNAs, some of which are rapidly degraded. I will present our work on the control of pervasive transcription by transcription termination mechanisms and on the coordination between termination and RNA degradation.